Clinical Trials & Research Made Quadramune Possible

COVID-19 is unlike anything we have ever seen before:

Life as we know it has changed

What is Coronavirus Disease (COVID-19)?

Caused by new coronavirus, SARS-CoV-2
Human originating coronaviruses cause common cold, this coronavirus is special because originated in bats and adapted to humans
Previous two coronaviruses that originated in bats

caused many deaths, but did not multiply, or mutate as fast

Lethality 3-5%, elderly and immune-compromised
Spreads extremely fast:
Takes 2 weeks to know if you are infected
Asymptomatic people can spread it
On average 1 person spreads it to 3 people
Compare with flu, 1 person spreads to 1.3 people

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Total Infected Patients

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Hospital Over Crowding

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Health Care Workers Needed

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Total Global Deaths

Our Immune System Protects Us from COVID19

Age Correlates with Weaker Immunity

With the onset of aging a greater risk of airborne infectious disease is more likely because of weaker immunity.

Innate and Adaptive
Immunity

Activates Innate and Adaptive Immunity to Stop Viral Propagation & Stimulate Immune Memory to Virus.

A Balance of Th1 and Th2
Cytokines

A gentle balance between Th1 cytokines and Th2 cytokines maintains the immune system and stops the propagation of viruses.

Adversely, Our Immune System Can Kill

COVID-19 deaths are result of acute respiratory distress syndrome (ARDS)
Excessive immune response to virus results in infiltration of inflammatory cells (neutrophils) into lung
Neutrophils produce enzymes which destroy the fine structures of the lung needed for respiration to occur, also causes leakage of water into lungs

Additional Production

Additional production from virus by enhancement of Th1 cells, which are part of the adaptive immune system and cause immunological memory.

CovidMune Boosts “Good” Immunity while Suppressing “Bad” Immunity

Protection by Stimulation

Protection from virus is mediated by stimulation of first layer of defense “innate” immunity: interferon alpha production NK cell activity.

Suppression of Inflammation

Suppression of excessive inflammation by inhibition of NLRP3 and chemicals that are toxic to lung.

CovidMune™: An Integrated Attack on COVID-19

Contains

Pterostilbene, which is the active ingredient in NanoStilbene™, originally developed and patented by us as a potent delivery means of using pterostilbene for immune stimulation and blocking inflammation is included.

Epigallocatechin gallate (EGCG) is potent antioxidant, responsible for some health benefits of green tea

Sulforaphane is an antioxidant and potent stimulator of endogenous detoxifying enzymes, responsible for health benefits of broccoli.

Thymoquinone is a phytochemical compound found in the plant Nigella sativa.

Therapeutic Solutions International, Inc.